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MG-132

参数名
参数值
别名
Z-VAD-FMK
CAS
187389-52-2
规格
5mg
单价:¥0.0
相关产品

 

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Product name

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MG-132, proteasome inhibitor

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Description

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Potent, reversible proteasome inhibitor

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Alternative names

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Z-LLL-CHO

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Biological description

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Potent, reversible, proteasome inhibitor (Ki = 4 nM). Inhibits NF-κB activation by preventing IκB degradation (IC50 = 3 μM). Anti-cancer properties in vitro and in vivo. Cell-permeable.

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Also available as ethanol solution (ab147047).

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Purity

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> 98%

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CAS Number

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133407-82-6

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Chemical structure

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Properties

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Molecular weight

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475.62

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Molecular formula

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C26H41N3O5

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Sequence

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LLL (Modifications: N-terminal benzyloxycarbonyl; C-terminal aldehyde)

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PubChem identifier

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462382

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Storage instructions

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Store at -20°C. It is important to note that this is air sensitive and impurities can occur as a result of air oxidation. Store under desiccating conditions.

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Solubility overview

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Soluble in DMSO to 100 mM but unstable for prolonged periods. Soluble in ethanol to 100 mM.

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Handling

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Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

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SMILES

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CC(C)CC(C=O)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)OCC1=CC=CC=C1

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Source

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Synthetic

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