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Z-FA-FMK

参数名
参数值
规格
5mg
CAS
187389-52-2
别名
Z-VAD-FMK
单价:¥0.0
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Caspases are a family of cytosolic aspartate-specific cysteine proteases involved in the initiation and execution of apoptosis. They are expressed as latent zymogens and are activated by an autoproteolytic mechanism or by processing by other proteases (frequently other caspases). Human caspases can be subdivided into three functional groups: cytokine activation (caspase-1, -4, -5, and -13), apoptosis initiation (caspase-2, -8, -9, -and -10), and apoptosis execution (caspase-3, -6, and -7).

 

Caspases are regulated by a variety of stimili, including APAF1, CFLAR/FLIP, NOL3/ARC, and members of the inhibitor of apoptosis (IAP) family such as BIRC1/NAIP, BIRC2/cIAP-1, BIRC3/cIAP-2, BIRC4/XIAP, BIRC5/Survivin, and BIRC7/Livin. IAP activity is modulated by DIABLO/SMAC or PRSS25/HTRA2/Omi. Cell-permeable and irreversible peptide inhibitors are also available for different caspases.

 

Specifications

Shipping Conditions The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Storage Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

Species Multi-Species

 

Formal Name

N-[(1S)-2-[(3-fluoro-1-methyl-2-oxopropyl)amino]-2-oxo-1-(phenylmethyl)ethyl]-carbamic acid, phenylmethyl ester

CAS Number

197855-65-5

Synonyms

Z-Phe-Ala-Fluoromethyl Ketone

Molecular Formula

C21H23FN2O4

Formula Weight

386.4

Purity

≥98%

Formulation

A crystalline solid

SMILES

O=C(N[C@@H](CC1=CC=CC=C1)C(NC(C)C(CF)=O)=O)OCC2=CC=CC=C2

InChi Code

InChI=1S/C21H23FN2O4/c1-15(19(25)13-22)23-20(26)18(12-16-8-4-2-5-9-16)24-21(27)28-14-17-10-6-3-7-11-17/h2-11,15,18H,12-14H2,1H3,(H,23,26)(H,24,27)/t15?,18-/m0/s1

InChi Key

ASXVEBPEZMSPHB-PKHIMPSTSA-N

Shipping & Storage Information

Storage

-20°C

Shipping

常温运输

Stability

≥ 2 years

Product Description

Z-FA-FMK is an irreversible inhibitor of cysteine proteases, including cathepsins B, L, and S, cruzain, and papain.1 It also inhibits effector caspases-2, -3, -6, and -7 (IC50 = 6-32 µM) without affecting the initiator caspases-8 and -10.2 Z-FA-FMK also modulates infection by certain bacteria, parasites, and viruses.3,4,5 It can be used both in cells and in vivo.4,5

 

WARNING This product is not for human or veterinary use.

 

Handling

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.


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